Reid said Rubio should be forced to "pay back all the money" he made as senator.
"I'm a Hillary supporter and I don't go the Trump way," he said.
Trump spoke Tuesday about the economy and trade policies.
Trump blasted Clinton's previous support for trade deals such as NAFTA and the TPP.
The two Florida Democrats are in a primary battle for the Senate.
"Of that there's no doubt," the United Kingdom Independence Party leader said.
"I do not tell them what to do, I never have," he said.
Trump will speak in Monessen, Pa.
"They basically hid the report from us," Rep. Elijah Cummings (D-Md.) said of Republicans.
"Now's the time to go after him," she said.