Vice President Biden seemed to give Alaska Gov. Sarah Palin (R) some space after she suddenly announced Friday she'd resign from office.

"I'm not going to second guess her," Biden told ABC News in an interview to be aired tomorrow morning.

Biden was Palin's Democratic counterpart during the 2008 presidential election, when the Alaska governor ran as the running mate of Sen. John McCainJohn McCainA stronger NATO for a safer world Drug importation won't save dollars or lives Dem rep Charlie Crist files for divorce MORE (R-Ariz.)

Far from reveling in Palin's resignation, Biden seemed to give Palin the benefit of the doubt.

"I don't know what prompted her decision to not only not run again and also to step down as a consequence of the decision not to run in 2010," Biden said. "And I take her at her word that it had a personal ingredient in it and you have to respect that."

Biden said that politics can often be very personal and difficult on families. Biden famously took office after his wife and daughter were killed in an automobile accident shortly after being elected at the age of 30.