“We have not had a confirmed administrator since 2006,” Sen. Tim KaineTim KaineGOP lawmaker breaks with Trump on government hiring freeze Former Clinton spokesman: Virginia elections will begin resistance to Trump Top Dem comes out against Tillerson ahead of key vote MORE (D-Va.) said ahead of the vote. “It will be a good thing for the mission and the country to confirm an administrator.”

Republican Sens. Ted CruzTed CruzTrump's America: Businessmen in, bureaucrats out When Trump says 'Make America Great Again,' he means it Booker is taking orders from corporate pharmaceuticals MORE (Texas), Ron JohnsonRon JohnsonOvernight Healthcare: GOP governors defend Medicaid expansion GOP senator: Let's work with Dems to 'fix' ObamaCare Right renews push for term limits as Trump takes power MORE (Wis.), Mike LeeMike LeeOvernight Finance: Trump takes US out of Pacific trade deal | WH says Trump has left his businesses | Lobbyists expect boom times GOP senator floats eliminating the corporate income tax Booker is taking orders from corporate pharmaceuticals MORE (Utah), Mike CrapoMike CrapoLive coverage of Sessions confirmation hearing Senate rejects Paul's balanced budget Dems attack Trump SEC pick's ties to Wall Street MORE (Idaho), James Risch (Idaho), Mitch McConnellMitch McConnellSanders set for clash with Trump’s budget pick Cabinet picks boost 2018 Dems Overnight Finance: Trump takes US out of Pacific trade deal | WH says Trump has left his businesses | Lobbyists expect boom times MORE and Rand PaulRand PaulTrump's CIA chief clears Senate Overnight Defense: Trump nominates Air Force secretary | Senate clears CIA director | Details on first drone strike under Trump Dems blast Trump plans for deep spending cuts MORE (Ky.) voted against Tavenner's nominations.

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Sen. Tom HarkinTom HarkinGrassley challenger no stranger to defying odds Clinton ally stands between Sanders and chairmanship dream Do candidates care about our health or just how much it costs? MORE (D-Iowa) had placed a hold on her nomination out of frustration with the administration’s plan to spend prevention funds on promotions for the Affordable Care Act. He lifted the hold earlier this month after he said enough light had been shined on the issue.

CMS administers the Medicare and Medicaid programs and is also charged with implementing most of Obama's healthcare law. Tavenner has been leading CMS on an acting basis.

Kaine said Tavenner, who is from Virginia, was the right pick because she would bring a patient-focused “nurse’s attitude” to CMS and she is an “expert” on finding healthcare cost savings.

Before the vote on Tavenner, the Senate also voted to approve the nomination of William Orrick to be U.S. District Judge for the Northern District of California. He was confirmed on a 56-41 vote.

Sen. Barbara BoxerBarbara BoxerTop Obama adviser signs with Hollywood talent agency: report 
Democrats vie for chance to take on Trump as California governor Feinstein to hold campaign fundraisers, a hint she'll run again MORE (D-Calif.) said she was glad Orrick got a vote because the Northern District of California has a judicial emergency with a caseload 24 percent higher than the national average.

“We all know justice delayed is justice denied,” Boxer said. “That’s why I’m excited we’re finally getting a vote on this nominee.”

Sen. Chuck GrassleyChuck GrassleySessions can put the brakes on criminal justice 'reform' GOP senator: Trump budget chief could face confirmation 'problems' Jeff Sessions will protect life MORE (R-Iowa) said he opposed Orrick's nomination because he  didn't like a judicial decision he made that maintained the “weak status quo” of immigration and border enforcement. He added that Orrick didn't answer all of his questions during his confirmation hearing with the Judiciary Committee, where Grassley serves as the ranking member.