“We have not had a confirmed administrator since 2006,” Sen. Tim KaineTim KaineSenate Democrats dig in as shutdown approaches Clinton reappears on Capitol Hill for Reid send-off Kaine: Flynn spreads conspiracy theories a child wouldn't believe MORE (D-Va.) said ahead of the vote. “It will be a good thing for the mission and the country to confirm an administrator.”

Republican Sens. Ted CruzTed CruzThe Hill's 12:30 Report Cruz defends Trump's Taiwan call Ark., Texas senators put cheese dip vs. queso to the test MORE (Texas), Ron JohnsonRon JohnsonOvernight Regulation: Obama's reg czar under pressure | Fight looms over Trump EPA pick Obama's regulatory czar under pressure to cutoff 'midnight rules' Week ahead: GOP quickly laying groundwork for reg rollback MORE (Wis.), Mike LeeMike LeeSenate sends annual defense bill to Obama's desk Overnight Healthcare: Medical cures bill finally heads to White House Overnight Energy: Trump taps EPA foe to head agency | Energy reform bill officially dead MORE (Utah), Mike CrapoMike CrapoRyan lights Capitol Christmas tree Ex-Im faces new problems with Trump GOP debates going big on tax reform MORE (Idaho), James Risch (Idaho), Mitch McConnellMitch McConnellSenate Democrats dig in as shutdown approaches Overnight Healthcare: Burwell huddles with Dems on fighting ObamaCare repeal Reid: Bring back the earmarks MORE and Rand PaulRand PaulBrexit leader Farage pushing US-UK trade deal to Trump Senate sends annual defense bill to Obama's desk GOP rep: Trump has 'extra-constitutional' view of presidency MORE (Ky.) voted against Tavenner's nominations.

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Sen. Tom HarkinTom HarkinGrassley challenger no stranger to defying odds Clinton ally stands between Sanders and chairmanship dream Do candidates care about our health or just how much it costs? MORE (D-Iowa) had placed a hold on her nomination out of frustration with the administration’s plan to spend prevention funds on promotions for the Affordable Care Act. He lifted the hold earlier this month after he said enough light had been shined on the issue.

CMS administers the Medicare and Medicaid programs and is also charged with implementing most of Obama's healthcare law. Tavenner has been leading CMS on an acting basis.

Kaine said Tavenner, who is from Virginia, was the right pick because she would bring a patient-focused “nurse’s attitude” to CMS and she is an “expert” on finding healthcare cost savings.

Before the vote on Tavenner, the Senate also voted to approve the nomination of William Orrick to be U.S. District Judge for the Northern District of California. He was confirmed on a 56-41 vote.

Sen. Barbara BoxerBarbara Boxer House passes water bill with Flint aid, drought relief Fight over water bill heats up in Senate Dem senator tears up in farewell speech MORE (D-Calif.) said she was glad Orrick got a vote because the Northern District of California has a judicial emergency with a caseload 24 percent higher than the national average.

“We all know justice delayed is justice denied,” Boxer said. “That’s why I’m excited we’re finally getting a vote on this nominee.”

Sen. Chuck GrassleyChuck GrassleyMnuchin, Price meet with GOP senators Business groups express support for Branstad nomination 10 no-brainer ways to cut healthcare costs without hurting quality MORE (R-Iowa) said he opposed Orrick's nomination because he  didn't like a judicial decision he made that maintained the “weak status quo” of immigration and border enforcement. He added that Orrick didn't answer all of his questions during his confirmation hearing with the Judiciary Committee, where Grassley serves as the ranking member.