Rubio was responding to a question from a constituent on why the immigration bill can’t be dealt with in a piecemeal approach rather than a large comprehensive bill. Rubio said that because immigration reform is “complex,” a large bill is the best approach. He said that border enforcement and worker visas have to be dealt with at the same time because the issues are "interwoven."

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“The problem with immigration though is that it is complex because it is all interwoven,” Rubio said. “It’s all related to each other. It’s literally impossible to do one part without doing the other.”

The Senate is expected to begin floor debate on the Border Security, Economic Opportunity, and Immigration Modernization Act later this month.

The bipartisan group of eight senators, known as the Gang of Eight, introduced S. 744, which would create a pathway to citizenship for illegal immigrants already in the country, toughen border security, create a guest worker program and boost high-skilled immigration.

Sens. Rubio, John McCainJohn McCainTrump’s feud with the press in the spotlight Republicans play clean up on Trump's foreign policy Graham: Free press and independent judiciary are worth fighting for MORE (R-Ariz.), Lindsey GrahamLindsey GrahamTrump’s feud with the press in the spotlight Senators eye new sanctions against Iran Republicans play clean up on Trump's foreign policy MORE (R-S.C.), Jeff FlakeJeff FlakeOvernight Tech: GOP chairman to propose high-skilled visa overhaul | Zuckerberg's 5,700 word letter | Tech lobbies gear up ahead of internet fight Senate Dem blasts GOP for trying to repeal broadband privacy rules Planned Parenthood targets GOP lawmakers amid ObamaCare protests MORE (R- Ariz.), Charles SchumerCharles SchumerOvernight Cybersecurity: Trump defends Flynn, blasts leaks | Yahoo fears further breach Overnight Finance: Trump's Labor pick withdraws | Ryan tries to save tax plan | Trump pushes tax reform with retailers Democrats declare victory after Puzder bows out MORE (D-N.Y.), Dick DurbinDick Durbin McConnell: I’m very sympathetic to 'Dreamers' Senate Dems move to nix Trump's deportation order Dem senators call for independent Flynn probe MORE (D-Ill.), Robert MenendezRobert MenendezSteve Mnuchin, foreclosure king, now runs your US Treasury Senate Dems move to nix Trump's deportation order Senators to Trump: We support additional Iran sanctions MORE (D-N.J.) and Michael BennetMichael BennetSenate advances Trump's Commerce pick Senate Dems move to nix Trump's deportation order Senators to Trump: We support additional Iran sanctions MORE (D-Co.) comprise the Gang of Eight.

The Senate Judiciary Committee passed the bill out of committee last month on a bipartisan vote. Rubio said more work is needed to improve the legislation so it can pass in the House.

“There will have to be improvements,” Rubio said. “Because the good thing is the American people, the vast majority of them throughout the political spectrum, have clearly said that they are prepared to responsibly deal with those that are here illegally, but they are only willing to do so if we can take measures that ensure that this problem will never happen again in the future. And so, if we can make sure we put in place enforcement mechanisms and a guest worker program that ensures this will never happen again in the future, we’re going to have responsible immigration reform. And if we don’t have that, then we won’t have immigration reform.”

Some Republicans have complained that the legislation is being rushed through, and that it would provide amnesty for illegal residents before strengthening border enforcement enough.

House Republicans have said they will produce their own immigration reform bill, but that it would likely be passed in pieces rather than one large comprehensive bill.